Tag Archives: sex hormones

Celebrating Mexico’s Contributions to the Birth Control Pill

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September 15 to October 15 is National Hispanic Heritage Month. We’re celebrating by shining the spotlight on Mexico’s role in developing the birth control pill, one of the most important medical breakthroughs of the 20th century.

Humanity cannot fully unlock its potential until we release the bonds of oppression from all marginalized groups.

Underneath the surface of a large swath of Southern Mexico’s jungles lay the enormous roots of a wild yam, Dioscorea composita, known locally as barbasco. Mostly it was considered a nuisance, as it could get in the way of subsistence agriculture, but it did have its uses in traditional medicine — and it would change history forever when scientists figured out how to wrest valuable chemical compounds from it, a discovery that led directly to the development of the birth control pill.

Russell Marker. Image: Penn State University ArchivesIn the 1940s, hormones held an untapped potential for research, but there was no cost-effective method of producing large quantities of them — including progesterone, the Pill’s essential ingredient. An American chemist named Russell Marker set out to find a way to synthesize progesterone in abundance, hypothesizing that plants from the genus Dioscorea, which includes yams and agaves, would be a good source for starting material. After some research, he set his sights on wild-growing yams that were found only in Mexico.

Marker’s hunch brought him south of the U.S. border, where locals helped him find and gather these yams, enabling him to develop a method for synthesizing large batches of progesterone — more than had ever been in one place. When pharmaceutical companies would not invest in further research in Mexico, Marker relocated to Mexico City and put his money where his mouth was. In January 1944, he co-founded a lab named Syntex — a portmanteau of “synthesis” and “Mexico” — devoted to finagling hormones from wild Mexican yams. That yam was called barbasco by the indigenous population, and it was the industry’s choice for the raw material in hormone synthesis. Continue reading →

The History of the Birth Control Pill, Part 2: Barbasco and the Roots of Hormonal Contraception

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Russell Marker. Image: Penn State University Archives

Russell Marker. Image: Penn State University Archives

Welcome to the second installment of our series chronicling the history of the birth control pill. Previously, we learned about the role a sex hormone called progesterone plays in inhibiting ovulation. Scientists had no easy way to isolate significant amounts of this chemical and wanted to find a quick and inexpensive method for synthesizing large quantities of progesterone.

Russell Marker was born to Maryland sharecroppers in 1903. Hoping to escape rural life, Marker was one of only two students in his junior-high class to attend high school. He graduated in three years and enrolled at the University of Maryland, where he earned bachelor’s and master’s degrees in chemistry. He needed one more class to receive his doctorate, but refused to take it, believing he had already mastered his chosen subject, organic chemistry. He was only interested in working in the lab and thought the required course would be a waste of his time. (The university did eventually award him an honorary doctorate in 1987.)

A wild-growing yam in Mexico provided chemicals that could be refined into progesterone, the active ingredient in the Pill.

At the time, the scientific community was abuzz with discoveries being made about hormones. They held tremendous potential for research, but scientists couldn’t figure out how to isolate large quantities of them for study. Up for a challenge, Marker set out to find a way to synthesize one hormone, called progesterone, in abundance. He hypothesized that plants from the genus Dioscorea, which includes yams and agaves, would be cheap sources of steroid hormones. Marker was specifically hoping to find plants rich in sapogenins, which are chemically similar to cholesterol. Continue reading →

Let’s Talk Contraception: Depo-Provera Injections, Another Progestin-Only Option

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Progestin-only birth control pills (POPs), also called the mini-pill, are good options for those who cannot take estrogen. But for those who have lots of trouble remembering to take a pill every day at the same time, Depo-Provera shots may be the way to go. Depo-Provera is medroxyprogesterone, a hormone similar to progesterone. It is given as a shot in a doctor’s office or a health center such as Planned Parenthood, and lasts for three months to prevent pregnancy. Sometimes it is used to treat other conditions, like endometriosis.

One Depo-Provera shot lasts for three months.

The first shot is given five days after you start your period or, if you do not plan to breastfeed, in the first five days after giving birth. You must not be pregnant when you get the shot because its effects may damage the developing fetus. But it’s OK to use Depo-Provera when breastfeeding, as long as you wait six weeks after giving birth before getting the shot. It’s given in your buttock or upper arm. You need to use a backup method like a condom for seven days after getting your first shot. And if you miss getting your regular 12-week injection by only a few days, you may need to get a pregnancy test before getting your next shot.

While you are on Depo shots, your period may change. You may have spotting, bleeding, or even no bleeding. Fifty percent of people who have been on Depo-Provera for one year have no bleeding at all. After stopping the shots, menstrual bleeding returns. Also, after stopping the shots, it may take nine to 10 months to get pregnant. Continue reading →

The History of the Birth Control Pill, Part 1: Hormones, Our “Chemical Messengers”

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Welcome to the first installment of our series chronicling the history of the birth control pill, from our discovery of how hormones work, to the synthesis of these hormones from an inedible wild Mexican yam, to the creation of a pill that changed the world.

Underneath the surface of a large swath of Southern Mexico’s jungles lay the enormous roots of a wild yam, Dioscorea composita, known locally as barbasco. Mostly it was considered a nuisance, as it could get in the way of subsistence agriculture, but it did have its uses. Indigenous people used it as a fish poison, and traditional Mesoamerican healers used it to treat rheumatism, snakebites, muscular pain, and skin conditions. When the root was fermented in alcohol and put on aching joints, it was believed to work as a pain reliever.

The idea of a birth control pill was born in 1912 when Margaret Sanger dreamed of a “magic pill.”

Barbasco’s medicinal uses might not be surprising, given that scientists derived a chemical from the yam that led to the development of cortisone and oral contraceptives, both of which had sizable impacts on medicine and society. Oral contraceptives would not have been possible without a cheap and abundant source of progesterone, which was easily synthesized from the root after an American chemist, Russell Marker, discovered a process for converting a cholesterol found in barbasco’s roots to progesterone, a key ingredient in the Pill.

In the decades before this chemist’s excursion to Mexico, first-wave feminism was brewing in turn-of-the-century United States, and birth-control pioneer Margaret Sanger demanded access to contraception — in 1915, she invented the term “birth control,” and as early as 1912, the idea of a birth control pill had been envisioned — again, by Sanger, who wrote of her hope for a “magic pill.” A nurse, Sanger was spurred to action by the horror of watching women die prematurely after having too many children, while other women died from botched abortions. Continue reading →

Let’s Talk Contraception: The Mini-Pill or Progestin-Only Pill

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Birth control pills usually contain progestin and estrogen, which are both sex hormones. Progestin-only birth control pills (POPs) are sometimes called the mini-pill because they don’t contain estrogen. If you are concerned about taking estrogens because you have high blood pressure, migraines, heart disease, or a history of blood clots, but still would like to take an oral contraceptive, this may be an option for you. It is also a good choice if you are a new mother and breastfeeding.

Progestin-only pills don’t contain estrogen, making them a good option for some people.

POPs are used in the same way as other birth control pills. They come in packs of 28 pills. You take one pill at the same time each day and after the last pill in the pack is taken, you start a new pack the next day; there is no skipping days. Because there is a slightly greater risk of becoming pregnant on progestin-only pills, you must be very careful to take each pill at the same time each day and never miss a day. If your period is late and you missed one or more pills or took them late, you may need to take a pregnancy test.

The effects of POPs are easily reversible and after stopping these pills your chances of getting pregnant should not be delayed. Continue reading →