Tag Archives: leukemia

STD Awareness: Can Gene Editing Cure HIV?

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For the first time in history, someone with HIV has been treated with cells edited in the lab. It was a bold attempt to try to replicate previous successes in “curing” HIV through bone marrow transplants, but the results were a mixed bag.

Your DNA is like a book, and each sentence is a gene. Imagine a word is misspelled. Sometimes, a misspelling won’t affect your ability to understand the sentence, but other times, it will be so bad that you’ll have trouble figuring out the intended meaning. Think of the difference between “I drive a car” and “I driv a car,” or “I like food” and “I like flod.” You might not be able to tell what that last sentence is even trying to say! Those misspellings are mutations, and sometimes mutations are relatively benign (“I driv a car”), while other times they can cause diseases (“I like flod”).

A mutated version of the CCR5 gene confers near-immunity to HIV — but increases susceptibility to other viruses.

CRISPR, pronounced crisper, is a powerful new technology that can edit genes. By cutting DNA at a specific location and replacing some of the letters in the genetic alphabet, CRISPR can edit genes like you can edit a document using “find and replace.” The hope is that, someday, CRISPR could be used to fight disease by tweaking faulty genes. Continue reading →

STD Awareness: Can HIV Be Cured Now?

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In 1991, when Timothy Ray Brown was in his 20s, he moved from the United States to Europe in search of adventure. His travels brought him to Berlin, where he put down roots and became a translator — but this newfound stability was quickly disrupted. A former boyfriend told him he had been diagnosed with HIV, the virus that causes AIDS, and suggested Brown be tested as well. The results were positive. Brown calculated he had about two more years left to live.

His fortunes changed the next year when antiretroviral drugs transformed HIV from a death sentence to a manageable chronic disease. Life went on. But 10 years later, in 2006, he started noticing changes. While he usually made a 14-mile round trip on his bike to and from work, a quick ride to a café one mile away left him so winded he had to stop halfway through.

We still don’t have an HIV cure that works for everyone.

He was diagnosed with leukemia, a type of cancer that affects certain types of blood cells. He immediately began chemotherapy, a taxing regimen that nearly killed him when an infection forced his doctors to induce a coma. And when the cancer came back, his doctors recommended a bone marrow transplant, which involved wiping out his immune system with drugs and radiation. A year later, after his leukemia came back, he received a second bone marrow transplant. Recovery was grueling. He descended into delirium, nearly went blind, and was temporarily paralyzed. He had to undergo physical therapy to relearn how to walk and talk.

Miraculously, he came out of this near-death experience in full remission from leukemia. But the bone marrow transplants hadn’t just gotten rid of his leukemia. They had gotten rid of his HIV infection, too. The media dubbed him the “Berlin patient.” Continue reading →

Pro-Choice Friday News Rundown

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  • scientist face maskThe GOP debates were last night. Just an FYI: Every single one of those dingbats has deplorable, antiquated views on women’s reproductive rights and health. (Bustle)
  • The foolery surrounding unfounded allegations that Planned Parenthood has been illegally selling fetal tissue has reached ASININE LOWS, people. (NYT)
  • And it’s helped three state governments reach their ultimate goal of defunding us and further chipping away at women’s reproductive rights. Alabama is the latest. (CNN)
  • Speaking of Ass Backward Alabama, these clowns tried to snatch the parental rights of a pregnant prison inmate to stop her from getting an abortion! What in the hell! (Guardian)
  • With regard to fetal tissue, several organizations agreed to speak with The New York Times about their involvement in obtaining fetal tissue for the purpose of medical research on numerous degenerative diseases, such as leukemia, Hodgkin’s lymphoma, Parkinson’s disease, and others. (NYT)
  • Scientific and medical research is already beginning to suffer as a result of this fetal tissue non-scandal. Colorado State University officials have suspended the school from acquiring fetal tissue from entities linked to Planned Parenthood until “Congressional investigations are concluded.” (RH Reality Check)
  • Thank you, Salon, for covering the facts of this debacle in a reasonable manner. And exposing the fact that Planned Parenthood has prevented possibly 3 million abortions in 2013 and 2014 by providing affordable or free birth control to those in need. (Salon)
  • Ebony has a magnificent piece on what you absolutely must know about Planned Parenthood and black women. (Ebony)
  • Warren Buffett has funded a birth control revolution on the down low?!? #WhoKnew (Bloomberg)
  • The Economist has quite the chilling piece on how “exceptionally deadly” childbirth is in the United States. Gee, almost seems like women should have a choice about whether or not they want to risk their lives giving birth to a child rather than having it forced upon them, right? (The Economist)
  • The birth control pill has prevented how many instances of cancer in the last decade?! (Time)
  • In case it slipped your mind, our senator, John McCain, is still The Worst. (Phoenix New Times)

Pro-Choice Friday News Rundown

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  • Because Planned Parenthood is so committed to women’s health and providing the best preventive care possible, we’ve just pledged to dedicate $3 million to launch an initiative to fight breast cancer with expanded screenings and education! Woo hoo! (MSNBC)
  • Dear Todd Akin, Your assertion that a woman’s body can “shut the whole thing down” to prevent herself from being impregnated by her rapist is the biggest crock of $&*% we’ve ever heard. Sincerely, Legitimate Ob/gyn Professionals (NYT)
  • You know who’s more extreme on abortion than Todd Akin? Mitt Romney’s running mate, Paul Ryan! Boom. (The Daily Beast)
  • Please take a look at this fantabulous video extolling a myriad of benefits of contraception. It is so worth your time. (Guttmacher)
  • The tone deaf GOP is going all in on a plan to abolish abortion, and they could give a friggin’ crap if you were “legitimately raped” or molested. (Jezebel)
  • Remember that one time when Paul Ryan co-sponsored legislation with Todd Akin using the language “forcible rape” instead of just plain “rape” — as if there were different categories and classifications of rape? Well, he now insists “rape is rape” and pretends like this is just basic common sense that he’s always embraced! HA! It’s unfortunate that rape wasn’t “rape” when he insisted upon using the “forcible rape” phrase in the No Taxpayer Funding for Abortion Act. (RH Reality Check)
  • The Daily Beast has an epic slideshow detailing the history of abortion rights in America. (Daily Beast)
  • It’s time to panic: Gonorrhea is becoming resistant to the only medical treatment left. (The Grio)
  • Isn’t it interesting that anti-choicers have taken extreme interest in a black woman’s death following an abortion (which is extremely rare), rather than the much higher rate of mortality among black women after childbirth? (Double X)
  • The Catholic Church: a long legacy of protecting the pre-born from not being born, but not protecting post-born children — from rape. (Gawker)
  • In related religious news, the Christian right’s affinity for the notion of fetal personhood has absolutely no scriptural basis. Whatsoever. (Role Reboot)
  • The scary world that awaits us if the GOP wins their war on a woman’s right to choose. (Mother Jones)
  • Medical science has proved that circumcision has significant health benefits, including decreasing the risk of cancer and lowering HIV transmission rates. However, circumcision rates are plummeting, which is probably going to cost the United States billions in health care costs. (USA Today)
  • Sadly, a young pregnant leukemia patient has died due to the failure of the Dominican Republic to allow her timely access to chemotherapy — all because because abortion is illegal in the DR and life-saving chemotherapy treatments are likely to terminate a pregnancy. (CNN)

STD Awareness: The Future of Treatment for HIV/AIDS

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This scanning electron micrograph shows HIV particles (colored yellow) infecting a human T cell. Image: National Institute of Allergy and Infectious Diseases, National Institutes of Health

This scanning electron micrograph shows HIV particles (colored yellow) infecting a human T cell. Image: National Institute of Allergy and Infectious Diseases, National Institutes of Health

In 2006, an HIV-positive man was diagnosed with leukemia. First he received chemotherapy, and when the cancer returned his doctor recommended a stem-cell transplant with tissues obtained from a bone-marrow donor. After finding an unusually high number of compatible donors, his doctor, Gero Hütter, had a simple idea that would change the course of HIV research. Dr. Hütter knew of a rare genetic mutation that confers immunity to many strains of HIV, including the strain that infected his cancer patient. And new blood cells, including immune cells, are manufactured by bone marrow. What if he could find a bone-marrow donor with this mutation? What effect would it have on the HIV infection?

Five years after his cancer diagnosis, the man, known as the Berlin patient and recently identified as Timothy Ray Brown, is in remission from cancer … and the most sensitive tests have been unable to detect HIV anywhere in his body, despite the discontinuation of antiretroviral drugs. Scientists are a cautious lot, careful not to make grand statements without qualifying them with words like “seem” and “suggest.” But more and more, researchers are starting to say that Brown could be the first case in which a cure for HIV was attained.

Human immunodeficiency virus, or HIV, has been the focus of intense research since the 1980s, when it was identified as the causative agent of AIDS. Many anti-HIV drugs have been developed since then, though worldwide, less than a third of people who need the drugs have access to them. Those with access, however, have significantly improved health outcomes and longer life expectancy. Continue reading →