Tag Archives: genetics

STD Awareness: Can Gene Editing Cure HIV?

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For the first time in history, someone with HIV has been treated with cells edited in the lab. It was a bold attempt to try to replicate previous successes in “curing” HIV through bone marrow transplants, but the results were a mixed bag.

Your DNA is like a book, and each sentence is a gene. Imagine a word is misspelled. Sometimes, a misspelling won’t affect your ability to understand the sentence, but other times, it will be so bad that you’ll have trouble figuring out the intended meaning. Think of the difference between “I drive a car” and “I driv a car,” or “I like food” and “I like flod.” You might not be able to tell what that last sentence is even trying to say! Those misspellings are mutations, and sometimes mutations are relatively benign (“I driv a car”), while other times they can cause diseases (“I like flod”).

A mutated version of the CCR5 gene confers near-immunity to HIV — but increases susceptibility to other viruses.

CRISPR, pronounced crisper, is a powerful new technology that can edit genes. By cutting DNA at a specific location and replacing some of the letters in the genetic alphabet, CRISPR can edit genes like you can edit a document using “find and replace.” The hope is that, someday, CRISPR could be used to fight disease by tweaking faulty genes. Continue reading →

Ending a Wanted Pregnancy: Jacqueline’s Story

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The following guest post comes to us via Jacqueline M.

My name is Jacqueline. I’m 31, part of the upper-middle class, happily married to the love of my life, and I had a second-trimester abortion.

My world turned upside down on February 4, 2019. At my 19.5-week ultrasound, the tech became strangely quiet following several minutes of joking with my husband and me. I thought nothing of it as my eyes obsessed over every inch of my little girl on the screen. The ultrasound complete, I cleaned the cold gel off of my belly and eagerly dressed to go speak with my PA.

“As all of my daydreams about raising a child vanished in an onslaught of medical terminology, my husband and I knew one thing: We could not put our daughter through the brief life of agony that awaited her.”

When she walked in the door, I excitedly gushed my questions and observations, which she answered without the enthusiasm I had come to expect during my appointments with her. When I finally paused, she looked me in the eye and said, “We’ve noticed what looks to be an omphalocele. Your daughter will need surgery the moment she is born to put her intestines back inside of her, but there is a 90 percent survival rate. There is also a 3-inch cyst on your ovaries. It’s so large that we can’t tell whether it’s on one or both, and we need to send you to a high-risk prenatal doctor.”

Sad and afraid, but determined, we went to see the high-risk OB the very next day. I was given a detailed level 2 ultrasound by a tech, and I took in all of the tiny details of my little girl that I wasn’t able to enjoy from the quality of my routine images: her tiny toes, a dainty hand, the small curve in her button nose. I gobbled her up, my daughter, my first child, still completely unaware of how terribly wrong my pregnancy had gone. Continue reading →

STD Awareness: Is Mouthwash a Match for Gonorrhea’s Superpowers?

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Since the 1930s, we’ve enjoyed around eight decades of easily cured gonorrhea — at least in places with easy access to antibiotics — but experts fear those days are numbered. In the past year or so, cases of untreatable gonorrhea have occasionally made headlines.

Thanks to the powers of evolution, some bacteria have acquired the multiple genes necessary to withstand the onslaught of the pills and shots administered by doctors. Gonococci, the bacteria that cause gonorrhea, are starting to win this “arms race” with humans, whose antibiotic arsenals are losing effectiveness. And with gonorrhea on the rise, gonococci may be evolving at an ever-quickening clip.

In 1879, Listerine claimed to cure gonorrhea. Today, scientists are finally testing that claim. We await the results.

Oral Gonorrhea: The Silent Scourge

Many experts believe oral gonorrhea is a key driver of antibiotic resistance. These infections usually don’t cause symptoms, and without symptoms people usually don’t seek treatment. Without treatment, gonococci can hang out in a throat for up to three months.

After transmission by oral sex — and possibly even by kissing  — gonococci can set up camp in the throat, which is an ideal environment for acquiring antibiotic resistance. They might not be causing symptoms, but they’re not sitting there twiddling their thumbs, either. If there’s one thing gonococci love to do, it’s collecting genes like some of us collect trading cards, and the throat is a gathering place for closely related bacteria species that hand out antibiotic-resistance genes for their expanding collections.

Gonococci can easily scavenge DNA from their surroundings — say, from a dead bacterium — and patch long segments of these genes into their own DNA, creating genetic hybrids between themselves and other organisms. Last month, scientists from Indiana University caught this phenomenon on video for the first time.

Continue reading →

STD Awareness: Why Should You Care About Oral Gonorrhea?

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Image: CDC

An illustration of Neisseria gonorrhoeae, the bacteria that cause gonorrhea. Image: CDC

When I say “gonorrhea,” you might think of genitals that feel as though they have been set ablaze, or perhaps a viscous fluid oozing from the urethra. But gonococci, the bacteria that cause gonorrhea, can also set up camp in the pharynx after being transmitted into a mouth and down a throat when its new host gave oral sex to its old host. Indeed, performing oral sex on multiple partners has been found to increase risk for an oral gonorrhea infection (more properly called pharyngeal gonorrhea).

If you read our September 2012 article on gonorrhea of the throat, you might remember these fun facts: Oral gonorrhea goes away within three months, even without treatment! Plus, these infections rarely have symptoms. Why, then, should you care about a gonorrhea infection in your throat? You’re not likely to notice it’s there, and it’ll go away on its own anyway.

Many researchers believe that the throat is an incubator for antibiotic-resistant gonorrhea.

Well, aside from the possibility of transmitting a gonorrhea infection from your throat to someone’s genitals, there’s one other thing to care about: the development of antibiotic resistance.

The emergence of antibiotic-resistant gonorrhea is considered one of the most pressing problems in infectious disease — just two years ago, the Centers for Disease Control and Prevention named it an “urgent threat,” and indeed, gonorrhea seems to be evolving resistance to drugs at quite a rapid clip. If gonorrhea evolves complete resistance to the drugs we use to cure it, we could find ourselves sent back in time, to the days when gonorrhea was untreatable — and responsible for infertility, blindness, and chronic pain. While scientists figure out how to address this emerging threat, you can do your part by avoiding gonorrhea in the first place — and that includes using condoms and dental dams to prevent oral gonorrhea infections.

So, while it sounds like a blessing that gonorrhea of the throat rarely has symptoms, there’s actually a drawback: An oral gonorrhea infection probably won’t be effectively treated — or even identified in the first place. And these hidden throat infections are likely to be helping to drive the development of antibiotic resistance. Continue reading →

STD Awareness: Genetics and the Gonococcus

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Image: CDC

Ever since the discovery of effective antibacterial therapies less than a century ago, humans have been able to easily cure gonorrhea, the sexually transmitted scourge that laid waste to fallopian tubes and robbed newborns of vision. Most of us in the developed world have forgotten that this disease was once a leading cause of infertility in women and blindness in babies — and still is in much of the developing world.

Unfortunately, gonococci — the species of bacteria that cause gonorrhea — have been evolving resistance to every antibiotic we’ve thrown at them, including sulfonamides, penicillins, tetracyclines, macrolides, fluoroquinolones, and narrow-spectrum cephalosporins. We have one remaining first-line gonorrhea treatment left: extended-spectrum cephalosporins, which include cefixime, which is taken orally, and ceftriaxone, which is administered as a shot — and resistance is emerging to those drugs, as well.

Gonococci don’t swap potato salad recipes at family reunions — they swap genetic material!

The emergence of antibiotic-resistant gonorrhea is considered one of the most pressing problems in infectious disease — just two years ago, the Centers for Disease Control and Prevention named it an “urgent threat,” and indeed, gonorrhea seems to be evolving resistance to drugs at quite a rapid clip. Gonococci can acquire resistance to antibiotics in three ways.

First, a genetic mutation can endow bacteria with special antibiotic-fighting powers, making it harder for a drug like penicillin to attach to their cells and destroy them. Such a mutant is more likely to gain evolutionary traction if it finds itself in an antibiotic-drenched environment in which resistance to that drug allows it to “outcompete” other bacteria. Indeed, antibiotic resistance was first documented in the 1940s, just years after sulfonamides and penicillin were introduced as the first effective cures for gonorrhea. Continue reading →

STD Awareness: Three Sexually Transmitted Bugs That Will Fascinate and Intrigue You

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From creepy crawly pubic lice, which can be seen with a magnifying glass, to minuscule human papillomaviruses, which can be seen with some of the most expensive microscopes in the world, there are many tiny pathogens that we can acquire through sexual contact. And, despite their diminutive sizes, some of them work in complicated ways, or tell stories about our origins that would blow you away. Let’s learn some amazing facts about three sexually transmitted bugs!

Phthirus pubis, the louse that causes scabies. Image from the Public Health Image Library.

Image: Public Health Image Library

Pubic lice: tiny insects that live in pubic hair

Fans of Charles Darwin might like learning about pubic lice, which offer clues about human evolution. While other apes’ bodies are habitat to only one species of louse, human bodies can host three different types of louse: head lice and the closely related body lice, as well as the distantly related pubic lice.

It is thought that when early humans lost their body hair, human lice followed this receding hairline and migrated to their heads to become head lice. At a later date, the gorilla louse colonized early humans’ pubic regions. Since pubic lice can be transmitted by infested bedding, one idea is that an early human caught pubic lice by sleeping in a burrow that had been recently vacated by a lice-ridden gorilla — no sexual contact required.

By examining the number of differences in the genetic codes of the modern gorilla louse and the human pubic louse, we can place their divergence into two separate species at about 3 million years ago, suggesting that our human ancestors lost their body hair at around that time.

A quite frankly weird fact about pubic lice involves the method their young use to hatch from their eggs — by releasing so much gas that the increase in air pressure causes them to burst from their shell. So there’s that. Continue reading →

Over 90 Percent of What Planned Parenthood Does, Part 24: Miscarriage Management and Counseling

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Welcome to the latest installment of “Over 90 Percent of What Planned Parenthood Does,” a series on Planned Parenthood Advocates of Arizona’s blog that highlights Planned Parenthood’s diverse array of services — the ones Jon Kyl never knew about.

holding handsMiscarriage. It’s a common occurrence — at least 10 to 15 percent of all pregnancies end this way — but one that is not often spoken about. When carrying a wanted pregnancy, its sudden loss can trigger a range of emotions. During this time, Planned Parenthood can help.

There is no “right” or “wrong” way to feel after having a miscarriage.

What Is Miscarriage?

When a pregnancy ends before it has reached the 20-week mark, a miscarriage has occurred; most miscarriages occur within the first eight weeks of pregnancy. Pregnancy loss after the 20-week mark is called stillbirth, and while it isn’t as common as miscarriage, stillbirth occurs in 1 out of 160 pregnancies.

Signs of a miscarriage include vaginal bleeding or spotting, severe abdominal pain or cramping, pain or pressure in the lower back, or a change in vaginal discharge. These symptoms aren’t specific to miscarriage — they could indicate other problems, so visit a health-care provider if you experience them during your pregnancy.

After a miscarriage, you might have pregnancy-related hormones circulating in your body for one or two months. Your period will most likely return within 4 to 6 weeks. While you may be physically ready to get pregnant again after you’ve had a normal period, you might want to consult with a health-care provider about the need for medical tests. You also might need to think about when you will be emotionally ready to try for another pregnancy. Continue reading →