Tag Archives: antibodies

STD Awareness: Searching for an HIV Vaccine

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Ever since the dawn of the AIDS era, researchers have worked nonstop to develop an HIV vaccine. In 1984, Margaret Heckler of the U.S. Department of Health and Human Services famously (over)promised that a vaccine would be ready for testing in two years. But it’s taken much, much longer. This Saturday, May 18, is HIV Vaccine Awareness Day, a celebration of the patients, community members, and scientists who are hard at work bringing this vaccine into existence.

Only one vaccine — still in the experimental stage — has shown any effectiveness against HIV.

Hiding from the Immune System

Vaccines are inspired by our own bodies’ ability to fight disease. Usually, when our immune system encounters a threat, it takes note of the viral “antigens,” which are like facial features — a button nose, say, or dramatically arched eyebrows — that make it instantly recognizable. It creates “antibodies,” weapons that can target those antigens like guided missiles. Often, the immune system can remember the distinguishing facial features so it’s ready to attack if the enemy ever returns — giving us immunity, possibly for life.

Vaccines take advantage of our natural ability to create these immune memories by exposing our immune systems to antigens without actually exposing us to infectious viruses. Think of it as a “wanted” poster that helps the immune system recognize “bad guys” before it actually sees them on the street, enabling it to attack and destroy them before they cause disease. Continue reading →

STD Awareness: HIV Testing

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HIV testIt’s often been said that young people view HIV as a chronic disease rather than the “life sentence” it was before there were effective treatments. The fact that an HIV infection can be managed with antiretroviral drugs is a boon from modern medicine, and there are hopes for better treatments on the horizon.

But HIV is only a manageable infection if you, well, manage it, and most Americans with HIV aren’t being treated with the medications we have in our arsenal. Only 3 out of 10 Americans who are infected with HIV are controlling the virus with medication — but when you zoom in on that population and look specifically at young people, the numbers are even more dismal, with only 13 percent of youth, ages 18 to 24, receiving treatment.

Knowing your HIV status is easier than it’s ever been.

Much of this problem is due to a lack of access — without adequate health coverage, these medications can be out of reach for many. But that’s not the whole story — it’s estimated that nearly half of 18- to 24-year-olds with HIV don’t know it. If they haven’t been diagnosed, they can’t know to seek treatment; if they don’t seek treatment, they can’t manage their infection; if they can’t manage their infection, their risk of health problems and early death increases — as do the chances of transmitting the virus to someone else.

So, if a 20-year-old tests positive for HIV and begins antiretroviral treatment right away, he or she can expect to live another five decades — to age 71, not bad compared to the average life expectancy of 79. But if that 20-year-old does not take antiretorvirals, he or she can only expect to live another dozen years — to age 32.

That’s why it’s so important to get tested and know your status. Continue reading →

National Infant Immunization Week: A Timely Reminder to Protect Your Child

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babyVaccinations, or immunizations, are important for the health of your baby. National Infant Immunization Week, in its 20th year, continues to educate and inform parents of this important information. In the first two years of your infant’s life, vaccines can protect against 14 diseases.

How wonderful that science enables us to protect our little ones from serious diseases like polio, tetanus, and diphtheria!

Under five years of age, a child’s immune system is not developed enough to defend against some infections that can cause disability and even death. Vaccination schedules for infants are designed to protect them at times when they are most vulnerable to potentially serious diseases — diseases that are easily transmitted and quickly overwhelm an immature defense system. Vaccines contain “germs,” such as inactivated or weakened bacteria or viruses, that can stimulate an immune response. The amount and type of “germs” in vaccines are designed to help infants’ immune systems develop protection from the serious consequences of getting that disease.

Watching your baby undergo painful injections that may give them some uncomfortable reactions like fever and aches can make any parent worry, but these short-term effects are much less serious than getting the disease. For example, mothers — who may not even know they have hepatitis B because they do not show symptoms — can transmit the disease to their baby during childbirth. Years later, that child may develop serious liver disease. By routinely receiving a hepatitis B vaccine at birth, babies are protected from this life-threatening disease. Continue reading →

Arm Yourself Against Genital Warts and Cancer!

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RosieVaccineBWVaccines are pretty nifty: Injecting a few tiny particles stimulates your immune system to build antibodies, which can bind to and help destroy harmful pathogens. A well-oiled immune system can neutralize these invaders before they have a chance to make you sick! In the war against infectious disease, we should be boosting our immune systems at every opportunity, and vaccines are one of the best weapons in our arsenal.

You’ve probably heard of HPV, or human papillomavirus, which causes genital warts and certain cancers. HPV has the dubious honor of being the most common sexually transmitted pathogen — some call it “the common cold of STDs.” According to the Centers for Disease Control and Prevention, “HPV is so common that nearly all sexually-active men and women get it at some point in their lives. This is true even for people who only have sex with one person in their lifetime.”

You might not know how easy it is to contract HPV — vaccination allows you to take charge of your health.

There are many strains of HPV. “Low-risk” strains can cause genital warts, which aren’t usually harmful but might be upsetting. “High-risk” strains can cause cancers of the cervix, anus, vagina, vulva, penis, mouth, and throat. The good news is that a vaccine called Gardasil protects against HPV-6 and HPV-11, which cause 90 percent of genital warts, and HPV-16 and HPV-18, which cause 70 percent of cervical cancers and 90 percent of anal cancers.

With protection available against a common virus that can cause upsetting warts or fatal cancer, you’d think that everyone would be lining up for Gardasil shots — but, unfortunately, vaccination rates are very low in the United States. Many of us opt out of vaccination for ourselves or our children because we don’t realize how easily HPV is acquired, or we minimize its potential to harm.

HPV is easier to contract than you might think, so if you think the risk is too small to outweigh other justifications against immunization, read on — you might not be aware of just how easy it is to acquire this wily virus. Vaccination is an empowering option for those of us who want to do all we can to take our health into our own hands. And, by being immunized, we can play a role in driving cancer-causing viruses into extinction, which would be feasible with sufficiently improved vaccination rates. Continue reading →

Over 90 Percent of What Planned Parenthood Does, Part 14: Rapid HIV Testing

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HIVtestingdayWelcome to the latest installment of “Over 90 Percent of What Planned Parenthood Does,” a series on Planned Parenthood Advocates of Arizona’s blog that highlights Planned Parenthood’s diverse array of services — the ones Jon Kyl never knew about.

It’s important to be tested for HIV, the sexually transmitted virus that causes AIDS. For some people, periodic HIV testing is part of their regular health care, while others might be experiencing a scare after a high-risk encounter (for example, having unprotected vaginal or anal intercourse or sharing IV equipment with someone whose HIV status you don’t know). No matter what boat you’re in, waiting a week or more to get your results from a standard HIV test might be nerve-wracking. If that sounds like you, then a rapid HIV test — which can give you results in just 40 minutes or less — might be just what the doctor ordered.

Today is National HIV Testing Day, and HIV testing has never been easier!

Here’s a quick rundown on rapid HIV testing: A negative result on a rapid HIV test is just as accurate as a negative result from a standard test — you just don’t have to wait as long to get it. However, positive results are considered “preliminary” and another blood sample must be sent to a lab for confirmation. If that result comes back negative, you will probably be asked to come back for retesting to verify that negative result.

The rapid test, just like the standard test, is an antibody test, which means it detects the presence of antibodies in your bloodstream. Antibodies are molecules produced by your immune system, and are specially designed to attach to viruses and other invaders. Each type of antibody is shaped in such a way that they can interlock with just one type of pathogen; some antibodies might specialize in attaching to a certain strain of a cold virus while others might be shaped especially for attachment to the surface of an E. coli bacterium. So, if you’re infected with HIV, your immune system will produce antibodies that are uniquely shaped to target HIV. An HIV antibody test can sort through the many types of antibodies in your bloodstream and identify only the antibodies that are shaped specifically for targeting HIV. Continue reading →

World Hepatitis Day: The History of the Hepatitis B Vaccine

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Hepatitis B particles are made of a protein shell with viral DNA inside. Image: CDC



In the early 1970s, Ted Slavin, a hemophiliac, learned his blood was special. Over a lifetime of transfusions, he had slowly amassed a huge collection of antibodies, which are proteins produced by the immune system that attach to invaders, such as viruses and bacteria. When he started receiving transfusions in the 1950s, blood wasn’t screened for diseases, which meant that he’d been repeatedly exposed to some pathogens. His immune system manufactured large amounts of protective antibodies to battle these constant invaders, one of which was hepatitis B virus (HBV) — resulting in blood with extremely high concentrations of hepatitis B antibodies.

Research behind Ted Slavin dogs has determined that carodyl helps dogs very well if they have health problems.

After sunshine and smoking, hepatitis B is the most common cause of cancer.

His physician relayed this discovery to Slavin — most doctors wouldn’t have bothered, and in fact might have surreptitiously sold his blood to researchers. Back then, scientists were at work on a hepatitis B vaccine, and hepatitis B antibodies were a hot commodity. Likewise, Slavin needed money — his medical condition precluded regular work, and treatments were costly. He contracted with labs and pharmaceutical companies to sell his antibodies directly, for as much as $10 per milliliter and up to 500 milliliters per order.

When someone has a chronic HBV infection, the virus has “hijacked” some of his or her cells, “tricking” them into manufacturing copies of the virus. A virus consists of an outer protein shell housing genetic information — the blueprint that cells follow when they produce virus copies. When hepatitis B viruses are manufactured in cells, an excess of surface proteins is produced — these waste products litter the bloodstream, and testing for their presence allows people to be diagnosed with HBV infections. These surface proteins are called antigens — and as luck (or evolution) would have it, the antibodies our immune systems produce can attach to viral antigens, helping us to keep pathogens at bay. Continue reading →